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Ji M, Zhang Y, Li N, Wang C, Xia R, Zhang Z et al (2017) Nicotine component of cigarette smoke extract (CSE) decreases the cytotoxicity of CSE in BEAS-2B cells stably expressing human cytochrome P450 2A13

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In 2018 FDA Tobacco Product Scientific Advisory Committee found that the IQOS did not substantially reduce risks of tobacco-related death and disease, and in 2019, FDA did not approve the products for a risk modification label

The inhalation of toxic substances in tobacco smoke, such as carbon monoxide and arsenic, poses severe health risks not only to smokers but also to non-smokers exposed to second-hand smoke