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Inhibitors of CYP2B6: Ticlopidine, Clopidogrel: In a trial in healthy male volunteers, clopidogrel 75 mg once daily or ticlopidine 250 mg twice daily increased exposures (Cmax and AUC) of bupropion by 40% and 60% for clopidogrel, and by 38% and 85% for ticlopidine, respectively

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Hence, the FDA recommends close monitoring of neuropsychiatric symptoms in patients receiving bupropion and to stop bupropion therapy if any contraindications were to be found ( 92 )