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There is no evidence to suggest that switching to lower nicotine cigarettes or electronic cigarettes helps to quit cigarette smoking altogether

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These findings should be interpreted with caution because this was a very short-term investigation (only 6 weeks), and the authors of that research had connections with nicotine pouch manufacturers [53]

Second, the study did not incorporate pharmacokinetic profiling, which limits our ability to fully explain whether reductions in nicotine and cotinine levels were due to altered metabolism, distribution, or clearance mechanisms

Frequent or chronic cannabis users may have longer detection windows compared to those who are frequent cannabis users smoking marijuana less frequently