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ACS Chem Neurosci 13(16):24362448 (American Chemical Society) de Montigny C, Chaput Y, Blier P (1990) Modification of serotonergic neuron properties by long-term treatment with serotonin reuptake blockers

The manufacturers of the devices report different heating temperatures

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This is when you start to feel good, and also a key thing that keeps you addicted. Essentially, nicotine taps into your brains reward pathways and starts to release dopamine and serotonin within about 10 to 20 seconds of your first inhale, giving you the pleasure response associated with smoking very rapidly

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