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The study protocol was approved by the Ethics Committee of Mario Negri Institute (Ethics Committee of Fondazione IRCCS Istituto Neurologico Carlo Besta, ID: 09, date: 9 November 2022)

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While Vt is a common PET outcome measure, SUV was used here because it avoids invasive arterial blood sampling and arterial sampling was not feasible at our site

Statistical analysis All statistical analyses were performed using GraphPad Prism 9.5.0 software

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