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In humans, depending upon their level of physical activity, 12 to 24 hr of fasting typically results in a 20% or greater decrease in serum glucose and depletion of the hepatic glycogen, accompanied by a switch to a metabolic mode in which nonhepatic glucose, fat-derived ketone bodies, and free fatty acids are used as energy sources. Longo & Mattson, 2014 But some of the benefits of daily fasting, or rather the effects of how we break our fasts, could depend on timing

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doi: 10.1016/j.ypmed.2017.04.001 16

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