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3 The self-medication hypothesis: a was first described by Khantzian to explain cocaine use by people with mental illnesses b has already been discarded by clinicians and policy makers c proposes that smoking reduces mortality rates in people with schizophrenia d proposes that people with schizophrenia tend to substitute antipsychotics with nicotine e is weakened by the finding that nicotine improves attention levels in people with schizophrenia to the same degree as in healthy controls

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Circulating proteins, however, may reflect not only smoking exposure as captured by DNA methylation but also the cumulative biological effects of responses to cigarette smoking (including oxidative stress or other mechanisms) or the biological responses to limit the hazards of smoking 9,14,15

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Bob Newhart: The Untold Story Of The Legendary Comedian Stand-up comedy as we know it today a single performer on a stage, delivering carefully written and rehearsed bits that point out the foibles and absurdities of life virtually begins with Bob Newhart