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The following factors were included as covariates for potential confounders or risk factors: sex (male or female), grade (7th, 8th, 9th, 10th, 11th, or 12th), academic performance (high, middle, or low), area of residence (metropolitan, urban, or rural), residence type (living with or without family), economic status (high, middle, or low), subjective health condition (healthy, normal, or unhealthy), physical activity over 1 h and five times per week (yes or no), drinking experience (yes or no), smoking status (never, ex-smoker, or current smoker), sleep satisfaction (satisfied, regular, or unsatisfied), stress perception (high, middle, or low), depressive symptoms in the past 12 months (yes or no), and year (2020, 2021, 2022, or 2023)

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Results The published scientific literature and unpublished internal tobacco company research can be grouped by laboratory experimental data (ie, impact of filter ventilation on smoke chemistry yields, in vitro mutagenicity, and in vivo animal studies) and human studies (ie, smoking behavior, exposure including observational studies and clinical trials, and long-term epidemiology)