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HY-E's studies are partially funded by the Science Academy's Young Scientists' Award Program (BAGEP)

If heart failure develops, it should be managed according to current standards of care, and discontinuation or dose reduction of the PPAR-gamma agonist must be considered

Decision Guidance Choose cagrilintide + tirzepatide when you want the strongest single-agent base (tirzepatide is FDA-approved and outperforms semaglutide head-to-head) plus amylin layering

Conclusions and future directions Current evidence supports a potential link between microvascular dysfunction and HC, HCHF or HFD-induced insulin resistance

Cell Death and Differentiation

Further analyses of plasma showed no other pro-atherosclerotic alterations, with comparable HDL cholesterol and glucose levels observed among the different groups of mice