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[55] tested the lung tissues of ten patients with COPD and ten normal subjects, respectively, and found that Notch1 was mainly expressed in endothelial cells, and was significantly decreased in the endothelial cells of patients with COPD

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Some common compounds found in herbal cigarette smoke include: Polycyclic aromatic hydrocarbons (PAHs) Carbon monoxide Volatile organic compounds (VOCs) Particulate matter These substances result from the combustion process, regardless of the plant material burned