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In a wake-up call for people who claim to be concerned about smoking-related disease and death, five prominent public health scholars warn that the "tremendous" harm-reducing potential of e-cigarettes could be nullified by panicky political responses to underage consumption and vaping-related lung injuries

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With continued substance consumption over time comes the potential for serious long-term medical complications, mental health conditions along with profound social and behavioral ramifications

Therefore, it seems that host factors, the dose of nicotine, and comorbidities determine the harmful or the protective effect of nicotine

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For example, vapes can contain Tetrahydrocannabinol (THC), the substance most commonly found in marijuana, as well as a variety of other substances