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This is consistent with reports that GSK3 promotes NRF2 degradation, whereas AKT-mediated phosphorylation of GSK3 inhibits this process, thereby stabilizing NRF2 and enhancing its nuclear localization 11,20,26,28

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Retrieved January 18, 2014

However, even when assuming that this was a causal relationship, these tax increases did not substantially impact real prices, did not prevent a widening price range between cheapest and most expensive FM-P products, and made little impact on the lowest price paid for RYO tobacco

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