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They are highly sensitive and can lose their effectiveness when exposed to fluctuating temperatures, air, or light

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Researchers at the Wellcome Trust Sanger Institute, the Los Alamos National Laboratory, and their collaborators identified several different mechanisms by which tobacco smoking causes mutations in DNA

Shew, H.D

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Otherwise, there is some degree of inference, since individuals usually have some variability across their cognitive abilities and skills pre-injury, and some changes may have happened in the intervening decades as a result of normal aging and the drug and alcohol use (although, with years of being clean and sober, some of the latter may have been mitigated)