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The status of cigarette smoking as a risk factor for BC is firmly established 10,11,12,13,14 , and smoking has been shown to be associated with shifts in EV cargo profiles associated with non-small cell lung cancer akin to the proteomic changes observed in this study 44

Many cigarettes also have various chemical additives which alter the flavor, make the nicotine more addictive, and enhance the burning properties of the blend

The industry had, at that point, never lost a lawsuit in more than 800 cases

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