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Further research, including direct comparisons with non-smokers and more detailed toxicological assessment, is needed to clarify the reproductive risks of E-cigarettes and guide fertility counseling

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Chronic nicotine use also leads to changes in multiple neurotransmitter systems, particularly increasing dopamine release in the reward pathway and altering nicotinic acetylcholine receptors (nAChRs)

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Unfortunately with lung cancer, there are no early warning signals