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TLR4 can initiate two signaling pathways depending on the adaptor protein activated: the MyD88-dependent pathway, which results in the activation of transcription factor NF-kB and the production of proinflammatory cytokines, and the TRIF-dependent pathway, which results in the activation of transcription factor IRF3, responsible for the transcription of type 1 interferon, and NF-kB (5355)

A subgroup analysis will be performed by race

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Altria also issued a statement confirming the talks