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Thus determining the overall smoking-related mortality rate in a population can pose a challenge, as all of these diseaseseven lung cancer to a relatively minor degreeappear in nonsmokers as well, making it difficult to determine the percentage of deaths that can be attributed to smoking

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The primary causes of infection-attributable cancers are human papillomavirus (HPV), hepatitis B virus (HBV), hepatitis C virus (HCV), and Helicobacter pylori (110)(226)(227)