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DNMT3L lacks DNA methyltransferase activity but it co-localizes with DNMT3A and DNMT3B and enhances their activity (Tadokoro et al., 2007), cooperating with DNMT1 in silencing tumor suppressor genes in colorectal cancer cells (Rhee et al., 2002), or regulating synaptic plasticity in the brain ( de novo DNMTs may influence how DNA methylation patterns are established during early embryogenesis

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