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While a moderate signal of efficacy for topiramate in reducing heavy drinking has been demonstrated, there have been no well-controlled or well-powered direct comparative trials of topiramate with other commonly prescribed alcohol pharmacotherapies to guide treatment practice

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doi: 10.1172/JCI94012 40 ChenJShiXDengYDangJLiuYZhaoJet al

Acompany your smoke with a fine Puerto Rican rum and you might never want to leave

She convinced her father to do the same

It can increase your risk for heart disease, vessel damage, blood clots, and heart attacks