The fact that i) these 8 patients were diagnosed years ago [12], ii) none of them originally experienced major vascular events (1 individual with the COL1A1 variant showed aortic ectasia, uncomplicated tortuous vertebral arteries, and left ventricular thickening), and iii) all underwent periodical vascular surveillance that resulted negative at the time of writing, suggests that the supposed genotype-phenotype correlations of these variants should not be considered valid in all cases
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"Smoking and pregnancy--a review on the first major environmental risk factor of the unborn"
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Mortality by smoking habit and cause Pipe and cigar smokers who had never regularly smoked cigarettes have been examined previously.6 Their mortality from the causes that were classified as closely related to smoking (cancers of the lung, other respiratory sites, and oesophagus
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