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Potential harm due to flavor chemicals is further supported by an in vitro study in which maltol increased secretion of IL-8 from BEAS-2B cells and decreased barrier function in human bronchial epithelial cells 30 and by animal studies in which maltol produced long-term adverse health effects in rats and dogs 31 and elicited liver and kidney damage in mice 32

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doi:10.1007/s10900-015-0114-1 Bahl, V., Jacob, P., Havel, C., Schick, S

Yes, and people have been doing it for decades