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side effects were reported mainly with 2 mg nicotine gums

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Antipsychotic medications have been found to impair glucose metabolism and clearance through antagonistic effects on H1 and 5-hydroxytryptamine 2A (5-HT2A), which normally both play roles in glycogen synthesis and glucose uptake, especially in skeletal muscle cells [29]

Thats a complicated answer with many nuances although an ever-growing body of evidence is certainly suggesting its potentially harm reduced relative to continued cigarette use

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