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They are often promoted as tobacco-free, but the nicotine may have been extracted from tobacco and may contain substances originally present in tobacco

Studies have shown that the amount of nicotine is much higher than that of approved nicotine replacement therapy tools, making them ineffective for those looking to quit tobacco

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Association study between oral metabolome and microbiota was carried out with the abundance of microbial genera in each sample and their metabolomic profiles using CCrepe package in R