For example, setting a threshold level of nicotine exposure below which it is not addictive is an extremely speculative tactic
It is a complicated procedure that lasts up to a year a period during which those cigarettes are still being sold. [C]ompanies use the text of the law, the literal understanding of the words of the law in the directive, and have come up with products that fool you to your face. In Hungary, Romania, and the U.K., JTI has admitted to concerned health officials that their products do contain menthol, but insisted the cigarettes lack a characterizing flavor, essentially daring them to prove otherwise
J Pharm Pharmacol 42 : 450452
These individual variations in nicotine tolerance are at least in part due to the pharmacogenetics of Cytochrome P450 2A6 (CYP2A6), the hepatic enzyme primarily responsible for nicotine metabolism [18]
It could even have benefits for the e-cig industry for example, if the well-resourced suppliers of other smokeless systems fund scientific research that demonstrates conclusively their safety or efficacy in smoking cessation
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