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Accessed 1/25/2021

At the methodological level, all selected studies were of good methodological quality, although the quality of evidence according to GRADE is low or very low in most cases

1994), after 24 years of follow-up the data showed not only that sustained smoking was associated with the size of decline of FEV 1 in males and females but also that younger quitters ( 4,600 total subjects

*THESE CIGARETTES DO NOT PRESENT A REDUCED RISK OF HARM COMPARED TO OTHER CIGARETTES

In 2014, PMI introduced IQOS only in Japan and Italy and was available in 37 countries by August 2018