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Moreover, the GBD methodology does not fully capture complex social and environmental determinants such as socio-economic status, cultural practices, and healthcare-system differences that could affect the generalizability and policy relevance of our findings

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Experts do not generally consider ibuprofen to be a medication that will lead to substance use disorder, although at least one The body does not build up a tolerance to it, so a person will not need larger doses for the same effect

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