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For youth there was a spike in the late 90s, the smoke rate being 34.8% in 1999 and by 2021 just 3.8%

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The traditional clonal origin of carcinogenesis states that transformation occurs through a series of sequential mutations resulting in preneoplastic lesions that progress to neoplasia and, finally, metastasis

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Recent Adv Tob Sci 21:3980 Zaridze DG, Kuvshinov JP, Matiakin E, Polakov BI, Boyle P, Blettner M (1985) Chemo prevention of oral and esophageal cancer in Uzbekistan, Union of Soviet Socialist Republics

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