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The central idea is that in fictive interaction, the frame of a face-to-face conversation is used in language to structure meanings that in fact involve no actual conversation

Pharmacol Biochem Behav 67 : 2528

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This can intensify side effects, lead to overdose, or cause adverse reactions

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This contributes to an insufficient compensatory response to insulin resistance and gluconeogenesis, mediated by the inhibition of hepatic AMP-activated protein kinase, thereby promoting the progression towards overt diabetes