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Psychosocial factors provide a potential biological explanation for the negative cardiovascular effects of early smoking initiation specific to adolescents and young adults

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6 Conflicting evidence on the role of MCPyV in LC development The role of Merkel cell polyomavirus (MCPyV) in lung cancer (LC) development remains controversial, with detection rates ranging from 0% to 39% across different studies ( Table 1 ), indicating unclear pathogenicity

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37 This being said, the identified dose-dependent associations in diffuse brain areas (including regions without evidence for a role in impulse control) and the apparent reversal of the effect of smoking on the cortex provide evidence that the differences in thickness do not mostly predate the onset of smoking