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Endothelial cells displayed characteristic features of pyroptosis in the aorta of nicotine-induced ApoE / mice Pyroptosis is uniquely dependent on the activation of caspase-1, which can process cytokines IL-1 and IL-18 into their active forms and then induce pyroptotic cell death

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that women show more resistance to nicotine replacement therapy and a greater tendency to relapse when trying to quit smoking

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