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The adverse effects of nicotine in the hepatic system include the upregulation of inflammatory cytokines, the development of secondary polycythemia, and blockage of proliferation and activation of apoptosis in lymphocytes

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However, doctors say it is also possible for cholesterol to increase too much during pregnancy, in a condition known as gestational hypercholesterolemia or maternal hypercholesterolemia

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Some other studies showed an increased risk for the United States, but not for the European region. It argued that the reason for low risk estimates from Europe and Americas might be due to difference in frequency and intensity of use and variation in SLT type

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