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With gastroesophageal reflux disease, the lower esophageal sphincter relaxes between swallows and after eating, allowing stomach contents and corrosive acid to back up and burn or irritate the lining of the esophagus

World No Tobacco Day is a significant annual event by the World Health Organization (WHO)

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Characteristically, patients exhibit skin thickening of the dorsum of the hands and feet and a relative loss of elasticity of the skin of the fingers that determines a certain retraction of the fingers and a phenomenon of pseudoleukonychia when stretching them since cutaneous bed is exsanguinated (Fig