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Exposure to cigarette smoke is also an important modifiable environmental risk factor for MS development and its clinical course ( The population attributable fraction (AF) of disease due to exposure, or the proportion of the disease in a population attributable to smoking, can be used to assess the contribution of smoking to the risk of disease development

[DOI] [PubMed] [Google Scholar] Lebowitz MD, Holberg CJ, Knudson RJ, Burrows B

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Motility disorders include achalasia, esophagogastric junction outflow obstruction, diffuse esophageal spasm, jackhammer esophagus, and absent contractility