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Smoking is one of the most important modifiable risk factors for many chronic diseases and death 10 , and smoking can damage almost all organs and systems of the body 11

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HBV+DEN-treated TregST2 CKO mice showed significantly lower liver tumor burden, improved liver architecture, and decreased PCNA + proliferating hepatocytes compared with HBV+DEN-treated WT mice at 8 months post-infection (Fig

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