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overall trends and interactions, among adults and among cigarette smokers), we compared models with survey wave analysed using restricted cubic splines with three, four, and five knots (sufficient to accurately model trends across years without overfitting) using the Akaike information criterion (AIC)

But while competing products such as e-cigarettes and snus promise harm reduction through consumer choice, a nicotine cap would be the opposite: harm maximization by government fiat.

The effects of tobacco use on oral health