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For example: nicotine - stimulates pleasure to the brain but also causes withdrawal symptoms and the need for more nicotine physical dependence - you smoke because youre in specific situation or with a specific group of people emotional dependence - you smoke to get away from emotional issues, or youre bored

Socioaffective Neuroscience & Psychology 3:20767

People who use smokeless tobacco and people who smoke have similar levels of nicotine in their blood

They still bear all the classic hallmarks of Innokin design, but with better functionality and flavour than ever before

Dual users had significantly experienced more adverse effects compared to exclusive e-cigarette users (Table 3)

Seidman LJ, Valera EM, Makris N (Jun2005) Structural brain imaging of attention-deficit/hyperactivity disorder