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Dual users of CCs and novel tobacco and nicotine products reported a higher number of different adverse events during or after cigarette smoking compared with CC-only smokers, highlighting the increasing harm of combining conventional and novel products

In trying to protect your mind from the neuro-chemical influence of the toxic natural pesticide nicotine, in some brain regions it actually desensitized important neuro-chemical circuits by reducing neurotransmitter receptor sites (down-regulation), in other regions by increasing the number of receptors (up-regulation), and still others by diminishing the number of transporters

Quality as defined in this context should be taken to refer only to nicotine content and not to sensory experience or quality of the tobacco leaf (although a nicotine reduction could also result in reduced consumer acceptability in terms of other characteristics)

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