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Excessive fission may lead to the production of non-functioning mitochondria, which may be removed from the network through autophagy or may merge with functional mitochondria, potentially spreading dysfunction

These include headaches, irritability and intense cravings

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This study found 'high-certainty' evidence that E-Cigarettes are more effective for quitting than traditional nicotine replacement therapy such as nicotine patches and nicotine gum

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