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A smoker just switches from one addition to another

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and of individuals with high polygenic risk, 1.77% (95% CI 1.352.27%) current and 1.34% (95% CI 1.171.53%) former smokers developed dementia compared with 1.05% (95% CI 0.911.21%) of never smokers (adjusted HR 1.63

Dividing this by the average nicotine content of a cigarette (1mg) gives an equivalence of 500 cigarettes for the entire bottle, though actual usage varies

BMC Med (2012) 10:99