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Clinically, these processes manifest themselves in the typical features of atrophic AMD: degeneration of the retinal pigment epithelium, formation of extracellular deposits such as drusen and thickening of Bruch's membrane

However it is widely recognized that even such an intensive regime does not adequately represent the extremes relevant for human smoking behavior

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Dunbar ZR, Das A, OConnor RJ, Goniewicz MJ, Wei B, Travers MJ (2018) Brief report: lead levels in selected electronic cigarettes from Canada and the United States