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Competing interests M.G.R is the founding editor of Epigenetics Communications and currently serves as coEditor-in-Chief.The other authors declare that they have no competing interests

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The data have been triangulated by studying various influencing factors and trends identified from both the demand and supply sides of various applications involved in the study

The 5% nicotine e-liquid increased plasma nicotine levels by about 50% and 65% at five and 35 minutes, respectively, compared to 1% nicotine