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These structures play a crucial role in regulating Ca 2 homeostasis through various signaling mechanisms: The IPR-VDAC-MCU Pathway facilitates Ca 2 transfer from the ER to mitochondria via inositol 1,4,5-trisphosphate receptors (IPRs) on the ER membrane, voltage-dependent anion channels (VDACs) on OMM, and MCU on IMM

This has been shown in tumor cells in the breast, colon, and lung

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In the bioecological model, development and health behaviors are understood as the product of ongoing, reciprocal interactions between the individual and the environment, with attributes such as temperament, health, and genetic predispositions shaping how these interactions unfold (Trucco, 2020

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