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150 Mast-cell-degranulation products, such as histamine, lipid mediators, and spingosine-1-phosphate, can activate immature DCs, trigger their mobilization to draining LNs, and induce the preferential priming of Th2 cells

In contrast, some modern alternatives are developed with sealed systems to help maintain consistency over time

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The company had recently launched its iQOS heated tobacco device, which it promoted as a potentially lower risk alternative to cigarettes