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Sustained NRF2 activation probably contributes to persistent antioxidant defense and cellular resilience during long-term oxidative challenge, consistent with observations that NRF2 signaling remains constitutively active in smoking-associated squamous carcinomas 29,30

When adjusting for age, sex, and race-ethnicity, we observed the positive correlation between tobacco exposure and epilepsy (OR 1.76, 95% CI [1.013.08])

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Comparatively, cigarette smokers tend to have a higher addiction level than smokeless tobacco users due to the higher nicotine content in cigarettes

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