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Specifically, we used a random intercept in the mixed-effects model to account for the within-study correlation and used a study-specific random slope with respect to the signal to capture between-study heterogeneity

Meeting 2-3 criteria equals mild, 4-5 equals moderate, 6+ equals severe

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(This was not widely reported until 2010, when Lorillard was finally held responsible in court by the estate of a lung cancer victim whose lifetime of smoking started at age nine with a Newport giveaway.) Newport also spent much of the 60s in an advertising arms race with Kool, with the goal of generating the greatest possible hip factor among young African-Americans

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