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The primary challenge was the extreme rarity of PNECs, which make up less than 1% of lung cells, making them nearly impossible to isolate and study in depth, Zhang said

Footnote xvii , Footnote xviii , Footnote xix , Footnote xx The promotion of tobacco through packages and products is particularly effective in adolescence and young adulthood, when brand loyalty and smoking behavior are beginning to be established

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Cigarettes contain additives to enhance tobacco's addictiveness and many people are unable to quit smoking despite repeated attempts

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The Environmental Protection Agency (EPA) advises users to bring their used e-cigarettes and other types of disposable cigarettes to a hazardous waste collection site where they dismantle the cigarettes and remove the components that are a threat for the environment, namely the lithium batteries and the e-liquid