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183186 Severe respiratory failure has been common, with a maximal level of respiratory support that has included high-flow nasal cannula support (up to 47% in 1 study), noninvasive positive-pressure ventilation (up to 30%), and endotracheal intubation and invasive mechanical ventilation (up to 22%)

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In contrast, the cough receptors are extrapulmonary, low threshold mechanosensors that originate in the nodose ganglia