Vascular endothelial cells produce and secrete many physiologically active substances including vasodilators, such as nitric oxide (NO), prostaglandin I 2 , C-type natriuretic peptide, and endothelium-derived vascular hyperpolarizing factor, and vasoconstrictors, such as endothelin, angiotensin II, prostaglandin H 2 and thromboxane A 2 [51, 52]
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Here is a small, practical playbook for the worst minutes, without the hospital-brochure tone.
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In cases of more dangerous spiders like black widows or brown recluses, you might notice a target-like pattern developing with a pale center surrounded by a red ring and then a whitish outer ring
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