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E-cigarettes (E-cigs) are devices designed to simulate the look and feel of a normal cigarette, they use batteries and have interchangeable e-liquid cartridges

Passive (a.k.a., experimenter-administered) exposure allows for the control of both dose and time of administration relative to other outcome measures (e.g., examination of brain activation after a discrete time period) (60)

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Yet some operations now cover hundreds of acres, a big undertaking when much of the work is still done by hand