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Microscopy was carried out with a fluorescent microscope Leica DMR, and images captured in gray level using MetaView software (Universal Imaging Corporation) and colored post-acquisition with ImageJ

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Manual physical therapy can help release tightness in certain pelvic/abdominal muscles and connective tissues

Nicotine gum, another popular nicotine replacement therapy, is designed to manage withdrawal symptoms and reduce cravings with a lower nicotine dose, making it an effective tool to manage cravings during the quitting process